Interactions of Staphylococcus aureus with the Human Microbiota
Sünje J. Pamp, National Food Institute
Why are some individuals colonized with Staphylococcus aureus, while others are not? One hypothesis is that S. aureus colonization is influenced by interactions with other members of the indigenous microbiota. Recent findings suggest that humans that do not carry S. aureus, instead carry bacteria that can inhibit S. aureus, and thus may prevent S. aureus colonization. Analyses of different sites in the nasal cavity revealed that microbial communities differed according to site epithelium type and S. aureus culture-based carriage status. Certain Corynebacterium species were identified as the most important microbial community determinants of S. aureus carriage in the samples from this study as well as in samples from the Human Microbiome Project. In vitro co-cultivation experiments provided supporting evidence of interactions among these species. These results highlight spatial variation in nasal microbial communities and differences in community composition between S. aureus carriers and non-carriers. The findings may lead to new strategies for predicting and preventing S. aureus colonization.