Center for Models of Life
Niels Bohr Institute
University of Copenhagen
Blegdamsvej 17
2100 Copenhagen Ř
Ph:   +45 353 25260
Fax:  +45 353 25425
Mail:  cmolnbi.dk
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Transcription dynamics and regulation

Transcription is a dynamic process dealing with RNA polymerase (RNAP), Promoters, and movement of RNAP interference along the DNA. Transcription initiation can be regulated by a number of proteins, including transcription factors and RNAP from convergent promoters. We build physical/mathematical models of this regulation in order to understand limits and possibilities af this essential nano-mechanical part of life.by RNA polymerase traffic in Escherichia coli.

Publications

Sneppen K, Dodd IB, Shearwin KE, Palmer AC, Schubert RA, Callen BP, Egan JB
A mathematical model for transcriptional interference by RNA polymerase traffic in Escherichia coli
J. Mol. Biol. 346 (2005)

Christian Garde, Thomas Bjarnsholt, Michael Givskov, Tim Holm Jakobsen, Morten Hentzer, Anetta Claussen, Kim Sneppen, Jesper Ferkinghoff-Borg and Thomas Sams
Quorum Sensing Regulation in Aeromonas hydrophila
J. Mol. Biol. 396 (2010)

Kim Sneppen, Sandeep Krishna, Szabolcs Semsey
Simplified Models of Biological Networks
Annual Review of Biophysics 39 (2010)

Mille A. Micheelsen, Namiko Mitarai, Kim Sneppen, Ian. B. Dodd
Theory for stability and regulation of epigenetic landscapes
Phys. Biol. 7 (2010)
1002.1600

Sandeep Krishna, Laszlo Orosz, Kim Sneppen, Sankar Adhya and Szabolcs Semsey
Relation of Intracellular Signal Levels and Promoter Activities in the gal Regulon of Escherichia coli
Journal of Molecular Biology 391 (2009)

Szabolcs Semsey, Sandeep Krishna, Janos Erdssy, Peter Horvath, Laszlo Orosz, Kim Sneppen and Sankar Adhya
Dominant Negative Autoregulation Limits Steady-State Repression Levels in Gene Networks
Journal of Bacteriology 191 (2009)

Hiizu Nakanishi, Margit Pedersen, Anne K. Alsing and Kim Sneppen
Modeling of the Genetic Switch of Bacteriophage TP901-1: A Heteromer of CI and MOR Ensures Robust Bistability
J. Mol. Biol. 394 (2009)
0908.4145

Simone Pigolotti, Sandeep Krishna, Mogens H. Jensen
Symbolic dynamics of biological feedback networks
Phys. Rev. Lett. 102 (2009)

Sandeep Krishna, Szabolcs Semsey, Kim Sneppen
Combinatorics of feedback in cellular uptake and metabolism of small molecules
PNAS 104 (2007)

Namiko Mitarai, Ian B. Dodd, Michael T. Crooks, Kim Sneppen
The Generation of Promoter-Mediated Transcriptional Noise in Bacteria
PLoS Comput. Biol. 4 (2008)

Kim Sneppen, Mille A Micheelsen & Ian B Dodd
Ultrasensitive gene regulation by positive feedback loops in nucleosome modification
Molecular Systems Biology 4 (2008)

Jacob Bock Axelsen, Sebastian Bernhardsson, Kim Sneppen
One Hub-One Process: A Tool Based View on Regulatory Network Topology
BMC Systems Biology 2 (2008)
0711.2208

I.B. Dodd, K.E. Shearwin and K. Sneppen
Modelling transcriptional interference and DNA looping in gene regulation
J. Mol. Biol. 369 (2007)

Alexander Hunziker, Csaba Tuboly, Péter Horváth, Sandeep Krishna, and Szabolcs Semsey
Genetic flexibility of regulatory networks
PNAS 0 (2010)