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Center for Models of Life
Niels Bohr Institute
University of Copenhagen
Blegdamsvej 17
2100 Copenhagen Ø
Mail:  cmolnbi.dk

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Oscillations in Genetic Networks

A number of genetic networks exhibit oscillations. In mamalian systems this include Hes, p53, NF-kB plus a number of hormones. We study dynamical models for oscillations with the aim of uncovering basic mechanism as well as functional purpose for observed oscillations.

Publications

Jacob Bock Axelsen and Kim Sneppen
Quantifying the benefits of translation regulation in the unfolded protein response
Phys. Biol. 1 (2004)

M.H. Jensen, G. Tiana and K. Sneppen
Sustained oscillations and time delays in gene expression of protein Hes1
Febs letters 541 (2003)

G. Tiana, M.H. Jensen and K. Sneppen
Time delay as a key to apoptosis induction in the p53 network
Eur. Phys. J. B 29 (2002)
cond-mat/0207236

G Tiana, S Krishna, S Pigolotti, M H Jensen and K Sneppen
Oscillations and temporal signalling in cells
Phys. Biol. 4 (2007)

Kim Sneppen, Sandeep Krishna, Szabolcs Semsey
Simplified Models of Biological Networks
Annual Review of Biophysics 39 (2010)

Peter B. Jensen, Lykke Pedersen, Sandeep Krishna and Mogens H. Jensen
A Wnt Oscillator Model for Somitogenesis
Biophysical Journal 98 (2010)

Alexander Hunziker, Mogens H Jensen, Sandeep Krishna
Stress-specific response of the p53-Mdm2 feedback loop
BMC Systems Biology 4 (2010)

Namiko Mitarai, Mogens Høgh Jensen, Szabolcs Semsey
Coupled Positive and Negative Feedbacks Produce Diverse Gene Expression Patterns in Colonies
mBio 6 (2015)

Kristian Moss Bendtsen, Mogens H. Jensen, Sandeep Krishna, Szabolcs Semsey
The role of mRNA and protein stability in the function of coupled positive and negative feedback systems in eukaryotic cells
Scientific Reports 5 (2015)