• Interactive Model of Dynamical Epigenetics
  
• Nucleosome Mediated Transcription Regulation
  

• Physics of Gene Regulations

  • Response dynamics of molecular networks

  • Transcription dynamics and regulation

  • Molecular switches and epigenetics

  • Translation dynamics and regulation

• Models of Biological circuits

  • Network measures and comparisons

  • Molecular Networks

  • Molecular switches and epigenetics

  • Oscillations in Genetic Networks

  • Transcription dynamics and regulation

  • Translation dynamics and regulation

• Networks and Communication

  • Hide and Seek on Networks

  • Hierarchical Networks

  • Internet

  • Network measures and comparisons

  • Social networking

  • City Networks

• Evolution and dynamical systems

  • Evolution, analysis and modeling

  • Dynamics of network structure

  • Collective Behaviour

  • Extended dynamical systems

Cells carry information handed down from their ancestors and are able to pass on information to their descendants. In many cases this ``memory" is epigenetic -- not stored in the DNA sequence -- allowing cells with identical DNA to maintain distinct properties. Epigenetic cell memory implies alternative states that are stable over time and are inherited through cell division. Mechanism for epigenetic cell memory invokes positive feedback loops, either on genes with mutual repression or, for eucaryotes, through recruited modifications of DNA bound nucleosomes.

Publications